{"id":32030,"date":"2014-03-15T17:35:08","date_gmt":"2014-03-15T15:35:08","guid":{"rendered":"https:\/\/oneearth-oneocean.com\/2014\/03\/15\/polystyrene-nanoparticles-perturb-lipid-membranes\/"},"modified":"2014-03-15T17:35:08","modified_gmt":"2014-03-15T15:35:08","slug":"polystyrene-nanoparticles-perturb-lipid-membranes","status":"publish","type":"post","link":"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/","title":{"rendered":"Polystyrene Nanoparticles Perturb Lipid Membranes"},"content":{"rendered":"
http:\/\/dx.doi.org\/10.1021\/jz402234c<\/a>\n\nGiulia Rossi, Jonathan Barnoud, and Luca Monticelli\nPolystyrene Nanoparticles Perturb Lipid Membranes\nJ. Phys. Chem. Lett., 2014, 5 (1), pp 241&ndash;246\nDOI: 10.1021\/jz402234c\nAbstract: Polystyrene is abundant in marine debris. Like most synthetic\npolymers, it degrades very slowly, producing smaller and smaller\nparticles easily ingested by wildlife. The presence of plastic\nmicroscopic particles in fish and marine wildlife is massive and well\ndocumented, but its impact on cellular activity is not understood.\nBiological activity generally requires interaction with biological\nmembranes, but this is difficult to study at the molecular scale in\nvivo. Here we use coarse-grained molecular simulations to determine the\neffect of nanosized polystyrene (PS) particles on the properties of\nmodel biological membranes. We find that PS nanoparticles permeate\neasily into lipid membranes. Dissolved in the membrane core, PS chains\nalter membrane structure, significantly reduce molecular diffusion, and\nsoften the membrane. Moreover, PS severely affects membrane lateral\norganization by stabilizing raft-like domains. Changes in membrane\nproperties and lateral organization can severely affect the activity of\nmembrane proteins and thereby cellular function.\nKeywords: lipid membranes; polymers; nanoparticle; coarse-grained\nmodels; molecular dynamics; rafts<\/pre>\n","protected":false},"excerpt":{"rendered":"
http:\/\/dx.doi.org\/10.1021\/jz402234c Giulia Rossi, Jonathan Barnoud, and Luca Monticelli Polystyrene Nanoparticles Perturb Lipid Membranes J. Phys. Chem. Lett., 2014, 5 (1), pp 241&ndash;246 DOI: 10.1021\/jz402234c Abstract: Polystyrene is abundant in marine debris. Like most synthetic polymers, it degrades very slowly, producing smaller and smaller particles easily ingested by wildlife. The presence of plastic microscopic particles in fish and marine wildlife is massive and well documented, but its impact on cellular activity is not understood. Biological activity generally requires interaction with biological membranes, but this is difficult to study at the molecular scale in vivo. Here we use coarse-grained molecular simulations to determine the effect of nanosized polystyrene (PS) particles on the properties of model biological membranes. We find that PS nanoparticles permeate easily into lipid membranes. Dissolved in the membrane core, PS chains alter membrane structure, significantly reduce molecular diffusion, and soften the membrane. Moreover, PS severely affects membrane lateral organization by stabilizing raft-like domains. Changes in membrane properties and lateral organization can severely affect the activity of membrane proteins and thereby cellular function. Keywords: lipid membranes; polymers; nanoparticle; coarse-grained models; molecular dynamics; rafts<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3504,3445,3423],"tags":[3717,3721,3535],"yoast_head":"\nPolystyrene Nanoparticles Perturb Lipid Membranes - One Earth - One Ocean e. V.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Polystyrene Nanoparticles Perturb Lipid Membranes - One Earth - One Ocean e. V.\" \/>\n<meta property=\"og:description\" content=\"http:\/\/dx.doi.org\/10.1021\/jz402234c Giulia Rossi, Jonathan Barnoud, and Luca Monticelli Polystyrene Nanoparticles Perturb Lipid Membranes J. Phys. Chem. Lett., 2014, 5 (1), pp 241&ndash;246 DOI: 10.1021\/jz402234c Abstract: Polystyrene is abundant in marine debris. Like most synthetic polymers, it degrades very slowly, producing smaller and smaller particles easily ingested by wildlife. The presence of plastic microscopic particles in fish and marine wildlife is massive and well documented, but its impact on cellular activity is not understood. Biological activity generally requires interaction with biological membranes, but this is difficult to study at the molecular scale in vivo. Here we use coarse-grained molecular simulations to determine the effect of nanosized polystyrene (PS) particles on the properties of model biological membranes. We find that PS nanoparticles permeate easily into lipid membranes. Dissolved in the membrane core, PS chains alter membrane structure, significantly reduce molecular diffusion, and soften the membrane. Moreover, PS severely affects membrane lateral organization by stabilizing raft-like domains. Changes in membrane properties and lateral organization can severely affect the activity of membrane proteins and thereby cellular function. 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V.\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/oeoo.world\/\" \/>\n<meta property=\"article:published_time\" content=\"2014-03-15T15:35:08+00:00\" \/>\n<meta name=\"author\" content=\"guenther\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"guenther\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/\"},\"author\":{\"name\":\"guenther\",\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/#\/schema\/person\/26a277b5ecd59a031fa6bd9553b40717\"},\"headline\":\"Polystyrene Nanoparticles Perturb Lipid Membranes\",\"datePublished\":\"2014-03-15T15:35:08+00:00\",\"dateModified\":\"2014-03-15T15:35:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/\"},\"wordCount\":5,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/#organization\"},\"keywords\":[\"nanoplastic\",\"polymers\",\"polystyrene (PS)\"],\"articleSection\":[\"2014\",\"object of research plastics\",\"research\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/\",\"url\":\"https:\/\/oneearth-oneocean.com\/en\/research-en\/2014\/polystyrene-nanoparticles-perturb-lipid-membranes\/\",\"name\":\"Polystyrene Nanoparticles Perturb Lipid Membranes - One Earth - One Ocean e. 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Biological activity generally requires interaction with biological membranes, but this is difficult to study at the molecular scale in vivo. Here we use coarse-grained molecular simulations to determine the effect of nanosized polystyrene (PS) particles on the properties of model biological membranes. We find that PS nanoparticles permeate easily into lipid membranes. Dissolved in the membrane core, PS chains alter membrane structure, significantly reduce molecular diffusion, and soften the membrane. Moreover, PS severely affects membrane lateral organization by stabilizing raft-like domains. Changes in membrane properties and lateral organization can severely affect the activity of membrane proteins and thereby cellular function. 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