{"id":27800,"date":"2021-08-27T12:06:45","date_gmt":"2021-08-27T10:06:45","guid":{"rendered":"https:\/\/oneearth-oneocean.com\/2021\/08\/27\/the-influence-of-microplastics-and-halogenated-contaminants-in-feed-on-toxicokinetics-and-gene-expression-in-european-seabass-dicentrarchus-labrax\/"},"modified":"2023-07-05T07:48:38","modified_gmt":"2023-07-05T05:48:38","slug":"the-influence-of-microplastics-and-halogenated-contaminants-in-feed-on-toxicokinetics-and-gene-expression-in-european-seabass-dicentrarchus-labrax","status":"publish","type":"post","link":"https:\/\/oneearth-oneocean.com\/en\/international-marine-litter-database-en-2\/2021\/the-influence-of-microplastics-and-halogenated-contaminants-in-feed-on-toxicokinetics-and-gene-expression-in-european-seabass-dicentrarchus-labrax\/","title":{"rendered":"The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax)"},"content":{"rendered":"<p>Kit Granby, Sandra Rainieri, Rie Romme Rasmussen, Michiel J.J. Kotterman, Jens J\u00f8rgen Sloth,<br \/>\nTommy Licht Cederberg, Alex Barranco, Ant\u00f3nio Marques, Bodil Katrine Larsen,<\/p>\n<p>The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax),<\/p>\n<p>Environmental Research,<br \/>\nVolume 164,<br \/>\n2018,<br \/>\nPages 430-443,<br \/>\nISSN 0013-9351,<\/p>\n<p>Abstract:<\/p>\n<p>When microplastics pollute fish habitats, it may be ingested<br \/>\nby fish, thereby contaminating fish with sorbed contaminants. The<br \/>\npresent study investigates how combinations of halogenated contaminants<br \/>\nand microplastics associated with feed are able to alter toxicokinetics<br \/>\nin European seabass and affect the fish. Microplastic particles (2%)<br \/>\nwere added to the feed either with sorbed contaminants or as a mixture<br \/>\nof clean microplastics and chemical contaminants, and compared to feed<br \/>\ncontaining contaminants without microplastics. For the contaminated<br \/>\nmicroplastic diet, the accumulation of polychlorinated biphenyls (PCBs)<br \/>\nand brominated flame retardants (BFRs) in fish was significantly higher,<br \/>\nincreasing up to 40 days of accumulation and then reversing to values<br \/>\ncomparable to the other diets at the end of accumulation. The<br \/>\nsignificant gene expression results of liver (cyp1a, il1\u03b2, gst\u03b1) after<br \/>\n40 days of exposure indicate that microplastics might indeed exacerbate<br \/>\nthe toxic effects (liver metabolism, immune system, oxidative stress) of<br \/>\nsome chemical contaminants sorbed to microplastics. Seabass quickly<br \/>\nmetabolised BDE99 to BDE47 by debromination, probably mediated by<br \/>\ndeiodinase enzymes, and unlike other contaminants, this metabolism was<br \/>\nunaffected by the presence of microplastics. For the other PCBs and<br \/>\nBFRs, the elimination coefficients were significantly lower in fish fed<br \/>\nthe diet with contaminants sorbed to microplastic compared to the other<br \/>\ndiets. The results indicate that microplastics affects liver<br \/>\ndetoxification and lipid distribution, both of which affect the<br \/>\nconcentration of contaminants.<\/p>\n<p><a href=\"https:\/\/drive.google.com\/open?id=1c3uQVivv0FV2n_yYbEAatccNUGlVjMdo\">https:\/\/drive.google.com\/open?id=1c3uQVivv0FV2n_yYbEAatccNUGlVjMdo<\/a><br \/>\nhttps:\/\/doi.org\/10.1016\/j.envres.2018.02.035.(http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0013935117313610)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kit Granby, Sandra Rainieri, Rie Romme Rasmussen, Michiel J.J. Kotterman, Jens J\u00f8rgen Sloth, Tommy Licht Cederberg, Alex Barranco, Ant\u00f3nio Marques, Bodil Katrine Larsen, The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax), Environmental Research, Volume 164, 2018, Pages 430-443, ISSN 0013-9351, Abstract: When microplastics pollute fish habitats, it may be ingested by fish, thereby contaminating fish with sorbed contaminants. The present study investigates how combinations of halogenated contaminants and microplastics associated with feed are able to alter toxicokinetics in European seabass and affect the fish. Microplastic particles (2%) were added to the feed either with sorbed contaminants or as a mixture of clean microplastics and chemical contaminants, and compared to feed containing contaminants without microplastics. For the contaminated microplastic diet, the accumulation of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) in fish was significantly higher, increasing up to 40 days of accumulation and then reversing to values comparable to the other diets at the end of accumulation. The significant gene expression results of liver (cyp1a, il1\u03b2, gst\u03b1) after 40 days of exposure indicate that microplastics might indeed exacerbate the toxic effects (liver metabolism, immune system, oxidative stress) of some chemical contaminants sorbed to microplastics. Seabass quickly metabolised BDE99 to BDE47 by debromination, probably mediated by deiodinase enzymes, and unlike other contaminants, this metabolism was unaffected by the presence of microplastics. For the other PCBs and BFRs, the elimination coefficients were significantly lower in fish fed the diet with contaminants sorbed to microplastic compared to the other diets. The results indicate that microplastics affects liver detoxification and lipid distribution, both of which affect the concentration of contaminants. https:\/\/drive.google.com\/open?id=1c3uQVivv0FV2n_yYbEAatccNUGlVjMdo https:\/\/doi.org\/10.1016\/j.envres.2018.02.035.(http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0013935117313610)<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2221],"tags":[1362,1363,1331,1364,1365],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax) - One Earth - One Ocean e. V.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/oneearth-oneocean.com\/en\/international-marine-litter-database-en-2\/2021\/the-influence-of-microplastics-and-halogenated-contaminants-in-feed-on-toxicokinetics-and-gene-expression-in-european-seabass-dicentrarchus-labrax\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax) - One Earth - One Ocean e. V.\" \/>\n<meta property=\"og:description\" content=\"Kit Granby, Sandra Rainieri, Rie Romme Rasmussen, Michiel J.J. Kotterman, Jens J\u00f8rgen Sloth, Tommy Licht Cederberg, Alex Barranco, Ant\u00f3nio Marques, Bodil Katrine Larsen, The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax), Environmental Research, Volume 164, 2018, Pages 430-443, ISSN 0013-9351, Abstract: When microplastics pollute fish habitats, it may be ingested by fish, thereby contaminating fish with sorbed contaminants. The present study investigates how combinations of halogenated contaminants and microplastics associated with feed are able to alter toxicokinetics in European seabass and affect the fish. Microplastic particles (2%) were added to the feed either with sorbed contaminants or as a mixture of clean microplastics and chemical contaminants, and compared to feed containing contaminants without microplastics. For the contaminated microplastic diet, the accumulation of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) in fish was significantly higher, increasing up to 40 days of accumulation and then reversing to values comparable to the other diets at the end of accumulation. The significant gene expression results of liver (cyp1a, il1\u03b2, gst\u03b1) after 40 days of exposure indicate that microplastics might indeed exacerbate the toxic effects (liver metabolism, immune system, oxidative stress) of some chemical contaminants sorbed to microplastics. Seabass quickly metabolised BDE99 to BDE47 by debromination, probably mediated by deiodinase enzymes, and unlike other contaminants, this metabolism was unaffected by the presence of microplastics. For the other PCBs and BFRs, the elimination coefficients were significantly lower in fish fed the diet with contaminants sorbed to microplastic compared to the other diets. The results indicate that microplastics affects liver detoxification and lipid distribution, both of which affect the concentration of contaminants. https:\/\/drive.google.com\/open?id=1c3uQVivv0FV2n_yYbEAatccNUGlVjMdo https:\/\/doi.org\/10.1016\/j.envres.2018.02.035.(http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0013935117313610)\" \/>\n<meta property=\"og:url\" content=\"https:\/\/oneearth-oneocean.com\/en\/international-marine-litter-database-en-2\/2021\/the-influence-of-microplastics-and-halogenated-contaminants-in-feed-on-toxicokinetics-and-gene-expression-in-european-seabass-dicentrarchus-labrax\/\" \/>\n<meta property=\"og:site_name\" content=\"One Earth - One Ocean e. 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Kotterman, Jens J\u00f8rgen Sloth, Tommy Licht Cederberg, Alex Barranco, Ant\u00f3nio Marques, Bodil Katrine Larsen, The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax), Environmental Research, Volume 164, 2018, Pages 430-443, ISSN 0013-9351, Abstract: When microplastics pollute fish habitats, it may be ingested by fish, thereby contaminating fish with sorbed contaminants. The present study investigates how combinations of halogenated contaminants and microplastics associated with feed are able to alter toxicokinetics in European seabass and affect the fish. Microplastic particles (2%) were added to the feed either with sorbed contaminants or as a mixture of clean microplastics and chemical contaminants, and compared to feed containing contaminants without microplastics. For the contaminated microplastic diet, the accumulation of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) in fish was significantly higher, increasing up to 40 days of accumulation and then reversing to values comparable to the other diets at the end of accumulation. The significant gene expression results of liver (cyp1a, il1\u03b2, gst\u03b1) after 40 days of exposure indicate that microplastics might indeed exacerbate the toxic effects (liver metabolism, immune system, oxidative stress) of some chemical contaminants sorbed to microplastics. Seabass quickly metabolised BDE99 to BDE47 by debromination, probably mediated by deiodinase enzymes, and unlike other contaminants, this metabolism was unaffected by the presence of microplastics. For the other PCBs and BFRs, the elimination coefficients were significantly lower in fish fed the diet with contaminants sorbed to microplastic compared to the other diets. 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